First published: 2024-09-18 / Last reviewed: 2026-05-28
This is a guide to PDRN injections compiled by Dr. Choi Byeong-geun of SHINE U Clinic Konkuk (3 minutes walk from Konkuk Univ. Station Exit 1).
Sometimes, after washing your face, you may notice that your skin has lost elasticity and wrinkles have deepened. It can be difficult to determine the condition of the skin's interior based solely on visible symptoms. Let's examine how skin boosters with polynucleotide ingredients work and in which layers.
Ingredients extracted from salmon
This skin booster involves injecting polynucleotides, a biocompatible substance extracted from salmon, into the skin to address its internal environment. Skin boosters are a method to improve skin texture by enhancing the skin's natural regenerative abilities. Since the medication is delivered directly, relatively quick changes can be expected, but the degree of change varies from person to person.
Hydration and collagen
- It addresses environments prone to fine wrinkles by deeply replenishing moisture.
- It promotes collagen production, helping to improve elasticity.
- It works to prevent sagging.
Fine wrinkles are also linked to a lack of moisture deep within the skin, so addressing deep hydration is fundamental.
How far does it reach: epidermis and dermis?
| Method | Scope of action |
|---|---|
| Sheet mask | Primarily epidermal layer |
| Polynucleotide skin booster | Epidermal and dermal layers |
Sheet masks provide moisture to the epidermal layer, but it's not easy for them to deliver it deep inside. This skin booster delivers moisture to the dermal layer and aids regeneration, working to strengthen thinned skin texture.
Consult about whether dryness or texture is more concerning
Regenerative ability and barrier
When regenerative ability declines, wrinkles increase, elasticity decreases, and damage may not heal well, leading to pigmentation. When the barrier weakens, moisture evaporates easily, and the skin becomes sensitive to external stimuli. By replenishing moisture, refining texture, and helping to strengthen the barrier, it contributes to calming sensitive skin.
Check and continue
This skin booster proceeds by identifying your skin type and addressing its deficiencies. The process also requires guidance on how to care for your skin after the treatment. However, suitability and results vary from person to person, so a prior check-up is important.
If you are concerned about dryness and skin texture, please inquire via consultation chat. Suitability can be confirmed through a consultation with Dr. Choi Byeong-geun.
Authored by: Dr. Choi Byeong-geun (Chief Director of SHINE U Clinic Konkuk / Member of Korean Academy of Laser Dermatology and Hair, Korean Academy of Aesthetic and Plastic Surgery Laser Medicine, Korean Filler Society, etc.) Last Reviewed: 2026-05-28
This article is for general information about procedures and does not replace diagnosis or treatment. The suitability and results of procedures may vary by individual.